Protein disulphide-isomerase reduces ricin to its A and B chains in the endoplasmic reticulum

Cells expressing ricin B chain within the secretory pathway are significantly more resistant to intoxication by ricin holotoxin but not to other cytotoxins that exploit similar endocytic routes to the cytosol. Furthermore, cells expressing the related B chain of abrin are protected against both inco...

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Detalhes bibliográficos
Main Authors: Spooner, Robert A., Watson, Peter D., Marsden, Catherine J., Smith, Daniel C., Moore, Katherine A. H., Cook, Jonathon P., Lord, J. Michael, Roberts, Lynne M.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134069/
https://ncbi.nlm.nih.gov/pubmed/15225124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040742
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