Ricin A Chain Insertion into Endoplasmic Reticulum Membranes Is Triggered by a Temperature Increase to 37 °C

After endocytic uptake by mammalian cells, the heterodimeric plant toxin ricin is transported to the endoplasmic reticulum (ER), where the ricin A chain (RTA) must cross the ER membrane to reach its ribosomal substrates. Here, using gel filtration chromatography, sedimentation, fluorescence, fluores...

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Autors principals: Mayerhofer, Peter U., Cook, Jonathan P., Wahlman, Judit, Pinheiro, Teresa T. J., Moore, Katherine A. H., Lord, J. Michael, Johnson, Arthur E., Roberts, Lynne M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2009
Matèries:
Membrane Transport, Structure, Function, and Biogenesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665077/
https://ncbi.nlm.nih.gov/pubmed/19211561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808387200
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