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Folding-competent and Folding-defective Forms of Ricin A Chain Have Different Fates after Retrotranslocation from the Endoplasmic Reticulum
We report that a toxic polypeptide retaining the potential to refold upon dislocation from the endoplasmic reticulum (ER) to the cytosol (ricin A chain; RTA) and a misfolded version that cannot (termed RTA(Δ)), follow ER-associated degradation (ERAD) pathways in Saccharomyces cerevisiae that substan...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The American Society for Cell Biology
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2912342/ https://ncbi.nlm.nih.gov/pubmed/20519439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-08-0743 |
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