Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum

The plant cytotoxin ricin enters target mammalian cells by receptor-mediated endocytosis and undergoes retrograde transport to the endoplasmic reticulum (ER). Here, its catalytic A chain (RTA) is reductively separated from the cell-binding B chain, and free RTA enters the cytosol where it inactivate...

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Autori principali: Spooner, Robert A., Hart, Philip J., Cook, Jonathan P., Pietroni, Paola, Rogon, Christian, Höhfeld, Jörg, Roberts, Lynne M., Lord, J. Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2580750/
https://ncbi.nlm.nih.gov/pubmed/18988734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809013105
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