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Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum
The plant cytotoxin ricin enters target mammalian cells by receptor-mediated endocytosis and undergoes retrograde transport to the endoplasmic reticulum (ER). Here, its catalytic A chain (RTA) is reductively separated from the cell-binding B chain, and free RTA enters the cytosol where it inactivate...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2580750/ https://ncbi.nlm.nih.gov/pubmed/18988734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809013105 |
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