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Cholera Toxin: An Intracellular Journey into the Cytosol by Way of the Endoplasmic Reticulum

Cholera toxin (CT), an AB(5)-subunit toxin, enters host cells by binding the ganglioside GM1 at the plasma membrane (PM) and travels retrograde through the trans-Golgi Network into the endoplasmic reticulum (ER). In the ER, a portion of CT, the enzymatic A1-chain, is unfolded by protein disulfide is...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wernick, Naomi L. B., Chinnapen, Daniel J.-F., Cho, Jin Ah, Lencer, Wayne I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Molecular Diversity Preservation International 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153193/
https://ncbi.nlm.nih.gov/pubmed/22069586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/toxins2030310
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