Transfer of the Cholera Toxin A1 Polypeptide from the Endoplasmic Reticulum to the Cytosol Is a Rapid Process Facilitated by the Endoplasmic Reticulum-Associated Degradation Pathway

The active pool of internalized cholera toxin (CT) moves from the endosomes to the Golgi apparatus en route to the endoplasmic reticulum (ER). The catalytic CTA1 polypeptide is then translocated from the ER to the cytosol, possibly through the action of the ER-associated degradation (ERAD) pathway....

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Detalhes bibliográficos
Main Authors: Teter, Ken, Allyn, Rebecca L., Jobling, Michael G., Holmes, Randall K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC130427/
https://ncbi.nlm.nih.gov/pubmed/12379694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.70.11.6166-6171.2002
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