Folding-competent and Folding-defective Forms of Ricin A Chain Have Different Fates after Retrotranslocation from the Endoplasmic Reticulum

We report that a toxic polypeptide retaining the potential to refold upon dislocation from the endoplasmic reticulum (ER) to the cytosol (ricin A chain; RTA) and a misfolded version that cannot (termed RTA(Δ)), follow ER-associated degradation (ERAD) pathways in Saccharomyces cerevisiae that substan...

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Autors principals: Li, Shuyu, Spooner, Robert A., Allen, Stuart C. H., Guise, Christopher P., Ladds, Graham, Schnöder, Tina, Schmitt, Manfred J., Lord, J. Michael, Roberts, Lynne M.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2010
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912342/
https://ncbi.nlm.nih.gov/pubmed/20519439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E09-08-0743
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