Protein disulphide-isomerase reduces ricin to its A and B chains in the endoplasmic reticulum

Cells expressing ricin B chain within the secretory pathway are significantly more resistant to intoxication by ricin holotoxin but not to other cytotoxins that exploit similar endocytic routes to the cytosol. Furthermore, cells expressing the related B chain of abrin are protected against both inco...

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Bibliografiska uppgifter
Huvudupphovsmän: Spooner, Robert A., Watson, Peter D., Marsden, Catherine J., Smith, Daniel C., Moore, Katherine A. H., Cook, Jonathon P., Lord, J. Michael, Roberts, Lynne M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Portland Press Ltd. 2004
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1134069/
https://ncbi.nlm.nih.gov/pubmed/15225124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20040742
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