Presenilin-dependent γ-secretase processing of β-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

Eitemau Tebyg

• Separation of presenilin function in amyloid β-peptide generation and endoproteolysis of Notch
  gan: Kulic, Luka, et al.
  Cyhoeddwyd: (2000)
• Presenilins mediate a dual intramembranous γ-secretase cleavage of Notch-1
  gan: Okochi, Masayasu, et al.
  Cyhoeddwyd: (2002)
• The presenilin C-terminus is required for ER-retention, nicastrin-binding and γ-secretase activity
  gan: Kaether, Christoph, et al.
  Cyhoeddwyd: (2004)
• Human CRB2 Inhibits γ-Secretase Cleavage of Amyloid Precursor Protein by Binding to the Presenilin Complex
  gan: Mitsuishi, Yachiyo, et al.
  Cyhoeddwyd: (2010)
• β-Amyloid Precursor Protein Mutants Respond to γ-Secretase Modulators
  gan: Page, Richard M., et al.
  Cyhoeddwyd: (2010)