Presenilin-dependent γ-secretase processing of β-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

The presenilin (PS)-dependent site 3 (S3) cleavage of Notch liberates its intracellular domain (NICD), which is required for Notch signaling. The similar γ-secretase cleavage of the β-amyloid precursor protein (βAPP) results in the secretion of amyloid β-peptide (Aβ). However, little is known about...

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Main Authors: Sastre, Magdalena, Steiner, Harald, Fuchs, Klaus, Capell, Anja, Multhaup, Gerd, Condron, Margaret M., Teplow, David B., Haass, Christian
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2001
Assuntos:
Scientific Reports
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1084035/
https://ncbi.nlm.nih.gov/pubmed/11520861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kve180
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