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Integrative analysis of RNA binding proteins identifies DDX55 as a novel regulator of 3’UTR isoform diversity

Abstract Background The 3’ untranslated regions (3’UTRs) of mRNAs play a critical role in controlling gene expression and function because they contain binding sites for microRNAs and RNA binding proteins (RBPs) that alter mRNA stability, localization, and translation. Most mRNA 3’ ends contain mult...

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Main Authors: Matthew R. Gazzara, Timothy Cater, Michael J. Mallory, Yoseph Barash, Kristen W. Lynch
Format: Artigo
Language:Inglês
Published: BMC 2025-11-01
Series:Genome Biology
Subjects:
Alternative Polyadenylation
DDX55
3’UTR
RNA Regulation
Online Access:https://doi.org/10.1186/s13059-025-03852-8
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