In vivo characterization of toxicity of norcocaethylene and norcocaine identified as the most toxic cocaine metabolites in male mice

av Zheng, Xirong, Shang, Linyue, Zhan, Chang-Guo, Zheng, Fang
I publikationen Drug Alcohol Depend (2019)

Kinetic characterization of human butyrylcholinesterase mutants for hydrolysis of cocaethylene

av Hou, Shurong, Zhan, Max, Zheng, Xirong, Zhan, Chang-Guo, Zheng, Fang
I publikationen Biochem J (2014)

Effects of a cocaine hydrolase engineered from human butyrylcholinesterase on metabolic profile of cocaine in rats

av Chen, Xiabin, Zheng, Xirong, Zhou, Ziyuan, Zhan, Chang-Guo, Zheng, Fang
I publikationen Chem Biol Interact (2016)

Blocking drug activation as a therapeutic strategy to attenuate acute toxicity and physiological effects of heroin

av Zhang, Ting, Zheng, Xirong, Kim, Kyungbo, Zheng, Fang, Zhan, Chang-Guo
I publikationen Sci Rep (2018)

Potential anti-obesity effects of a long-acting cocaine hydrolase

av Zheng, Xirong, Deng, Jing, Zhang, Ting, Yao, Jianzhuang, Zheng, Fang, Zhan, Chang-Guo
I publikationen Chem Biol Interact (2016)

A quantitative LC-MS/MS method for simultaneous determination of cocaine and its metabolites in whole blood

av Chen, Xiabin, Zheng, Xirong, Ding, Kai, Zhou, Ziyuan, Zhan, Chang-Guo, Zheng, Fang
I publikationen J Pharm Biomed Anal (2016)

Metabolic Enzymes of Cocaine Metabolite Benzoylecgonine

av Chen, Xiabin, Zheng, Xirong, Zhan, Max, Zhou, Ziyuan, Zhan, Chang-Guo, Zheng, Fang
I publikationen ACS Chem Biol (2016)

Catalytic activities of cocaine hydrolases against the most toxic cocaine metabolite norcocaethylene

av Zheng, Xirong, Chen, Xiabin, Zhang, Ting, Zhan, Max, Zhan, Chang-Guo, Zheng, Fang
I publikationen Org Biomol Chem (2020)

Clinical Potential of an Enzyme-based Novel Therapy for Cocaine Overdose

av Zhang, Ting, Zheng, Xirong, Zhou, Ziyuan, Chen, Xiabin, Jin, Zhenyu, Deng, Jing, Zhan, Chang-Guo, Zheng, Fang
I publikationen Sci Rep (2017)

Development of a Long-acting Fc-fused Cocaine Hydrolase with Improved Yield of Protein Expression

av Chen, Xiabin, Deng, Jing, Zheng, Xirong, Zhang, Jinling, Zhou, Ziyuan, Wei, Huimei, Zhan, Chang-Guo, Zheng, Fang
I publikationen Chem Biol Interact (2019)

Effectiveness of a Cocaine Hydrolase for Cocaine Toxicity Treatment in Male and Female Rats

av Zheng, Xirong, Zhou, Ziyuan, Zhang, Ting, Jin, Zhenyu, Chen, Xiabin, Deng, Jing, Zhan, Chang-Guo, Zheng, Fang
I publikationen AAPS J (2017)

Bench‐to‐bedside translation of chimeric antigen receptor (CAR) T cells using a multiscale systems pharmacokinetic‐pharmacodynamic model: A case study with anti‐BCMA CAR‐T...

av Singh, Aman P., Chen, Wenbo, Zheng, Xirong, Mody, Hardik, Carpenter, Thomas J., Zong, Alice, Heald, Donald L.
I publikationen CPT Pharmacometrics Syst Pharmacol (2021)

Development of a novel prostate apoptosis response-4 (Par-4) protein entity with an extended duration of action for therapeutic treatment of cancer

av Kim, Kyungbo, Araujo, Pereira, Hebbar, Nikhil, Zhou, Ziyuan, Zheng, Xirong, Zheng, Fang, Rangnekar, Vivek M, Zhan, Chang-Guo
I publikationen Protein Eng Des Sel (2019)

Kinetic Characterization of a Cocaine Hydrolase Engineered from Mouse Butyrylcholinesterase

av Chen, Xiabin, Huang, Xiaoqin, Geng, Liyi, Xue, Liu, Hou, Shurong, Zheng, Xirong, Brimijoin, Stephen, Zheng, Fang, Zhan, Chang-Guo
I publikationen Biochem J (2015)

Design, synthesis, and discovery of 5-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones and related derivatives as novel inhibitors of mPGES-1

av Ding, Kai, Zhou, Ziyuan, Zhou, Shuo, Yuan, Yaxia, Kim, Kyungbo, Zhang, Ting, Zheng, Xirong, Zheng, Fang, Zhan, Chang-Guo
I publikationen Bioorg Med Chem Lett (2018)

Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model

av Singh, Aman P., Zheng, Xirong, Lin-Schmidt, Xiefan, Chen, Wenbo, Carpenter, Thomas J., Zong, Alice, Wang, Weirong, Heald, Donald L.
I publikationen MAbs (2019)

Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs

av Ding, Kai, Zhou, Ziyuan, Hou, Shurong, Yuan, Yaxia, Zhou, Shuo, Zheng, Xirong, Chen, Jianzhong, Loftin, Charles, Zheng, Fang, Zhan, Chang-Guo
I publikationen Sci Rep (2018)

Model-based Cellular Kinetic Analysis of Chimeric Antigen Receptor-T Cells in Humans

av Liu, Can, Ayyar, Vivaswath S., Zheng, Xirong, Chen, Wenbo, Zheng, Songmao, Mody, Hardik, Wang, Weirong, Heald, Donald, Singh, Aman P., Cao, Yanguang
I publikationen Clin Pharmacol Ther (2020)

Development of Fc-fused Cocaine Hydrolase for Cocaine Addiction Treatment: Catalytic and Pharmacokinetic Properties

av Chen, Xiabin, Deng, Jing, Cui, Wenpeng, Hou, Shurong, Zhang, Jinling, Zheng, Xirong, Ding, Xin, Wei, Huimei, Zhou, Ziyuan, Kim, Kyungbo, Zhan, Chang-Guo, Zheng, Fang
I publikationen AAPS J (2018)