In vivo characterization of toxicity of norcocaethylene and norcocaine identified as the most toxic cocaine metabolites in male mice

Por Zheng, Xirong, Shang, Linyue, Zhan, Chang-Guo, Zheng, Fang
Publicado no Drug Alcohol Depend (2019)

Kinetic characterization of human butyrylcholinesterase mutants for hydrolysis of cocaethylene

Por Hou, Shurong, Zhan, Max, Zheng, Xirong, Zhan, Chang-Guo, Zheng, Fang
Publicado no Biochem J (2014)

Effects of a cocaine hydrolase engineered from human butyrylcholinesterase on metabolic profile of cocaine in rats

Por Chen, Xiabin, Zheng, Xirong, Zhou, Ziyuan, Zhan, Chang-Guo, Zheng, Fang
Publicado no Chem Biol Interact (2016)

Blocking drug activation as a therapeutic strategy to attenuate acute toxicity and physiological effects of heroin

Por Zhang, Ting, Zheng, Xirong, Kim, Kyungbo, Zheng, Fang, Zhan, Chang-Guo
Publicado no Sci Rep (2018)

Potential anti-obesity effects of a long-acting cocaine hydrolase

Por Zheng, Xirong, Deng, Jing, Zhang, Ting, Yao, Jianzhuang, Zheng, Fang, Zhan, Chang-Guo
Publicado no Chem Biol Interact (2016)

A quantitative LC-MS/MS method for simultaneous determination of cocaine and its metabolites in whole blood

Por Chen, Xiabin, Zheng, Xirong, Ding, Kai, Zhou, Ziyuan, Zhan, Chang-Guo, Zheng, Fang
Publicado no J Pharm Biomed Anal (2016)

Metabolic Enzymes of Cocaine Metabolite Benzoylecgonine

Por Chen, Xiabin, Zheng, Xirong, Zhan, Max, Zhou, Ziyuan, Zhan, Chang-Guo, Zheng, Fang
Publicado no ACS Chem Biol (2016)

Catalytic activities of cocaine hydrolases against the most toxic cocaine metabolite norcocaethylene

Por Zheng, Xirong, Chen, Xiabin, Zhang, Ting, Zhan, Max, Zhan, Chang-Guo, Zheng, Fang
Publicado no Org Biomol Chem (2020)

Clinical Potential of an Enzyme-based Novel Therapy for Cocaine Overdose

Por Zhang, Ting, Zheng, Xirong, Zhou, Ziyuan, Chen, Xiabin, Jin, Zhenyu, Deng, Jing, Zhan, Chang-Guo, Zheng, Fang
Publicado no Sci Rep (2017)

Development of a Long-acting Fc-fused Cocaine Hydrolase with Improved Yield of Protein Expression

Por Chen, Xiabin, Deng, Jing, Zheng, Xirong, Zhang, Jinling, Zhou, Ziyuan, Wei, Huimei, Zhan, Chang-Guo, Zheng, Fang
Publicado no Chem Biol Interact (2019)

Effectiveness of a Cocaine Hydrolase for Cocaine Toxicity Treatment in Male and Female Rats

Por Zheng, Xirong, Zhou, Ziyuan, Zhang, Ting, Jin, Zhenyu, Chen, Xiabin, Deng, Jing, Zhan, Chang-Guo, Zheng, Fang
Publicado no AAPS J (2017)

Development of a novel prostate apoptosis response-4 (Par-4) protein entity with an extended duration of action for therapeutic treatment of cancer

Por Kim, Kyungbo, Araujo, Pereira, Hebbar, Nikhil, Zhou, Ziyuan, Zheng, Xirong, Zheng, Fang, Rangnekar, Vivek M, Zhan, Chang-Guo
Publicado no Protein Eng Des Sel (2019)

Kinetic Characterization of a Cocaine Hydrolase Engineered from Mouse Butyrylcholinesterase

Por Chen, Xiabin, Huang, Xiaoqin, Geng, Liyi, Xue, Liu, Hou, Shurong, Zheng, Xirong, Brimijoin, Stephen, Zheng, Fang, Zhan, Chang-Guo
Publicado no Biochem J (2015)

Design, synthesis, and discovery of 5-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones and related derivatives as novel inhibitors of mPGES-1

Por Ding, Kai, Zhou, Ziyuan, Zhou, Shuo, Yuan, Yaxia, Kim, Kyungbo, Zhang, Ting, Zheng, Xirong, Zheng, Fang, Zhan, Chang-Guo
Publicado no Bioorg Med Chem Lett (2018)

Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model

Por Singh, Aman P., Zheng, Xirong, Lin-Schmidt, Xiefan, Chen, Wenbo, Carpenter, Thomas J., Zong, Alice, Wang, Weirong, Heald, Donald L.
Publicado no MAbs (2019)

Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs

Por Ding, Kai, Zhou, Ziyuan, Hou, Shurong, Yuan, Yaxia, Zhou, Shuo, Zheng, Xirong, Chen, Jianzhong, Loftin, Charles, Zheng, Fang, Zhan, Chang-Guo
Publicado no Sci Rep (2018)

Development of Fc-fused Cocaine Hydrolase for Cocaine Addiction Treatment: Catalytic and Pharmacokinetic Properties

Por Chen, Xiabin, Deng, Jing, Cui, Wenpeng, Hou, Shurong, Zhang, Jinling, Zheng, Xirong, Ding, Xin, Wei, Huimei, Zhou, Ziyuan, Kim, Kyungbo, Zhan, Chang-Guo, Zheng, Fang
Publicado no AAPS J (2018)