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Effects of a cocaine hydrolase engineered from human butyrylcholinesterase on metabolic profile of cocaine in rats
Accelerating cocaine metabolism through enzymatic hydrolysis at cocaine benzoyl ester is recognized as a promising therapeutic approach for cocaine abuse treatment. Our more recently designed A199S/F227A/S287G/A328W/Y332G mutant of human BChE, denoted as cocaine hydrolase-3 (CocH3), has a considerab...
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| Vydáno v: | Chem Biol Interact |
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| Hlavní autoři: | , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5094907/ https://ncbi.nlm.nih.gov/pubmed/27154495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2016.05.003 |
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