Preparation and in vivo characterization of a cocaine hydrolase engineered from human butyrylcholinesterase for metabolizing cocaine

Cocaine is a widely abused drug without an FDA-approved medication. It has been recognized as an ideal anti-cocaine medication to accelerate cocaine metabolism producing biologically inactive metabolites via a route similar to the primary cocaine-metabolizing pathway, i.e. human butyrylcholinesteras...

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Détails bibliographiques
Publié dans:Biochem J
Auteurs principaux: Xue, Liu, Hou, Shurong, Tong, Min, Fang, Lei, Chen, Xiabin, Jin, Zhenyu, Tai, Hsin-Hsiung, Zheng, Fang, Zhan, Chang-Guo
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4365901/
https://ncbi.nlm.nih.gov/pubmed/23849058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20130549
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