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Development of a Long-acting Fc-fused Cocaine Hydrolase with Improved Yield of Protein Expression
Human butyrylcholinesterase (BChE) is known as a safe and effective protein for detoxification of organophosphorus (OP) nerve agents. Its rationally designed mutants with considerably improved catalytic activity against cocaine, known as cocaine hydrolases (CocHs), are recognized as the most promisi...
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| Publicado en: | Chem Biol Interact |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6555559/ https://ncbi.nlm.nih.gov/pubmed/30986387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2019.04.012 |
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