Development of Fc-fused Cocaine Hydrolase for Cocaine Addiction Treatment: Catalytic and Pharmacokinetic Properties

Cocaine abuse is a world-wide public health and social problem without a U.S. Food and Drug Administration (FDA)-approved medication. Accelerating cocaine metabolism that produces biologically inactive metabolites by administration of an efficient cocaine hydrolase (CocH) has been recognized as a pr...

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Detalhes bibliográficos
Publicado no:AAPS J
Main Authors: Chen, Xiabin, Deng, Jing, Cui, Wenpeng, Hou, Shurong, Zhang, Jinling, Zheng, Xirong, Ding, Xin, Wei, Huimei, Zhou, Ziyuan, Kim, Kyungbo, Zhan, Chang-Guo, Zheng, Fang
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7734446/
https://ncbi.nlm.nih.gov/pubmed/29556863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-018-0214-9
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