In vivo characterization of toxicity of norcocaethylene and norcocaine identified as the most toxic cocaine metabolites in male mice

door Zheng, Xirong, Shang, Linyue, Zhan, Chang-Guo, Zheng, Fang
Gepubliceerd in Drug Alcohol Depend (2019)

Kinetic characterization of human butyrylcholinesterase mutants for hydrolysis of cocaethylene

door Hou, Shurong, Zhan, Max, Zheng, Xirong, Zhan, Chang-Guo, Zheng, Fang
Gepubliceerd in Biochem J (2014)

Effects of a cocaine hydrolase engineered from human butyrylcholinesterase on metabolic profile of cocaine in rats

door Chen, Xiabin, Zheng, Xirong, Zhou, Ziyuan, Zhan, Chang-Guo, Zheng, Fang
Gepubliceerd in Chem Biol Interact (2016)

Blocking drug activation as a therapeutic strategy to attenuate acute toxicity and physiological effects of heroin

door Zhang, Ting, Zheng, Xirong, Kim, Kyungbo, Zheng, Fang, Zhan, Chang-Guo
Gepubliceerd in Sci Rep (2018)

Potential anti-obesity effects of a long-acting cocaine hydrolase

door Zheng, Xirong, Deng, Jing, Zhang, Ting, Yao, Jianzhuang, Zheng, Fang, Zhan, Chang-Guo
Gepubliceerd in Chem Biol Interact (2016)

A quantitative LC-MS/MS method for simultaneous determination of cocaine and its metabolites in whole blood

door Chen, Xiabin, Zheng, Xirong, Ding, Kai, Zhou, Ziyuan, Zhan, Chang-Guo, Zheng, Fang
Gepubliceerd in J Pharm Biomed Anal (2016)

Metabolic Enzymes of Cocaine Metabolite Benzoylecgonine

door Chen, Xiabin, Zheng, Xirong, Zhan, Max, Zhou, Ziyuan, Zhan, Chang-Guo, Zheng, Fang
Gepubliceerd in ACS Chem Biol (2016)

Catalytic activities of cocaine hydrolases against the most toxic cocaine metabolite norcocaethylene

door Zheng, Xirong, Chen, Xiabin, Zhang, Ting, Zhan, Max, Zhan, Chang-Guo, Zheng, Fang
Gepubliceerd in Org Biomol Chem (2020)

Clinical Potential of an Enzyme-based Novel Therapy for Cocaine Overdose

door Zhang, Ting, Zheng, Xirong, Zhou, Ziyuan, Chen, Xiabin, Jin, Zhenyu, Deng, Jing, Zhan, Chang-Guo, Zheng, Fang
Gepubliceerd in Sci Rep (2017)

Development of a Long-acting Fc-fused Cocaine Hydrolase with Improved Yield of Protein Expression

door Chen, Xiabin, Deng, Jing, Zheng, Xirong, Zhang, Jinling, Zhou, Ziyuan, Wei, Huimei, Zhan, Chang-Guo, Zheng, Fang
Gepubliceerd in Chem Biol Interact (2019)

Effectiveness of a Cocaine Hydrolase for Cocaine Toxicity Treatment in Male and Female Rats

door Zheng, Xirong, Zhou, Ziyuan, Zhang, Ting, Jin, Zhenyu, Chen, Xiabin, Deng, Jing, Zhan, Chang-Guo, Zheng, Fang
Gepubliceerd in AAPS J (2017)

Bench‐to‐bedside translation of chimeric antigen receptor (CAR) T cells using a multiscale systems pharmacokinetic‐pharmacodynamic model: A case study with anti‐BCMA CAR‐T...

door Singh, Aman P., Chen, Wenbo, Zheng, Xirong, Mody, Hardik, Carpenter, Thomas J., Zong, Alice, Heald, Donald L.
Gepubliceerd in CPT Pharmacometrics Syst Pharmacol (2021)

Development of a novel prostate apoptosis response-4 (Par-4) protein entity with an extended duration of action for therapeutic treatment of cancer

door Kim, Kyungbo, Araujo, Pereira, Hebbar, Nikhil, Zhou, Ziyuan, Zheng, Xirong, Zheng, Fang, Rangnekar, Vivek M, Zhan, Chang-Guo
Gepubliceerd in Protein Eng Des Sel (2019)

Kinetic Characterization of a Cocaine Hydrolase Engineered from Mouse Butyrylcholinesterase

door Chen, Xiabin, Huang, Xiaoqin, Geng, Liyi, Xue, Liu, Hou, Shurong, Zheng, Xirong, Brimijoin, Stephen, Zheng, Fang, Zhan, Chang-Guo
Gepubliceerd in Biochem J (2015)

Design, synthesis, and discovery of 5-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones and related derivatives as novel inhibitors of mPGES-1

door Ding, Kai, Zhou, Ziyuan, Zhou, Shuo, Yuan, Yaxia, Kim, Kyungbo, Zhang, Ting, Zheng, Xirong, Zheng, Fang, Zhan, Chang-Guo
Gepubliceerd in Bioorg Med Chem Lett (2018)

Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model

door Singh, Aman P., Zheng, Xirong, Lin-Schmidt, Xiefan, Chen, Wenbo, Carpenter, Thomas J., Zong, Alice, Wang, Weirong, Heald, Donald L.
Gepubliceerd in MAbs (2019)

Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs

door Ding, Kai, Zhou, Ziyuan, Hou, Shurong, Yuan, Yaxia, Zhou, Shuo, Zheng, Xirong, Chen, Jianzhong, Loftin, Charles, Zheng, Fang, Zhan, Chang-Guo
Gepubliceerd in Sci Rep (2018)

Model-based Cellular Kinetic Analysis of Chimeric Antigen Receptor-T Cells in Humans

door Liu, Can, Ayyar, Vivaswath S., Zheng, Xirong, Chen, Wenbo, Zheng, Songmao, Mody, Hardik, Wang, Weirong, Heald, Donald, Singh, Aman P., Cao, Yanguang
Gepubliceerd in Clin Pharmacol Ther (2020)

Development of Fc-fused Cocaine Hydrolase for Cocaine Addiction Treatment: Catalytic and Pharmacokinetic Properties

door Chen, Xiabin, Deng, Jing, Cui, Wenpeng, Hou, Shurong, Zhang, Jinling, Zheng, Xirong, Ding, Xin, Wei, Huimei, Zhou, Ziyuan, Kim, Kyungbo, Zhan, Chang-Guo, Zheng, Fang
Gepubliceerd in AAPS J (2018)