In vivo characterization of toxicity of norcocaethylene and norcocaine identified as the most toxic cocaine metabolites in male mice

gan Zheng, Xirong, Shang, Linyue, Zhan, Chang-Guo, Zheng, Fang
Cyhoeddwyd yn Drug Alcohol Depend (2019)

Kinetic characterization of human butyrylcholinesterase mutants for hydrolysis of cocaethylene

gan Hou, Shurong, Zhan, Max, Zheng, Xirong, Zhan, Chang-Guo, Zheng, Fang
Cyhoeddwyd yn Biochem J (2014)

Effects of a cocaine hydrolase engineered from human butyrylcholinesterase on metabolic profile of cocaine in rats

gan Chen, Xiabin, Zheng, Xirong, Zhou, Ziyuan, Zhan, Chang-Guo, Zheng, Fang
Cyhoeddwyd yn Chem Biol Interact (2016)

Blocking drug activation as a therapeutic strategy to attenuate acute toxicity and physiological effects of heroin

gan Zhang, Ting, Zheng, Xirong, Kim, Kyungbo, Zheng, Fang, Zhan, Chang-Guo
Cyhoeddwyd yn Sci Rep (2018)

Potential anti-obesity effects of a long-acting cocaine hydrolase

gan Zheng, Xirong, Deng, Jing, Zhang, Ting, Yao, Jianzhuang, Zheng, Fang, Zhan, Chang-Guo
Cyhoeddwyd yn Chem Biol Interact (2016)

A quantitative LC-MS/MS method for simultaneous determination of cocaine and its metabolites in whole blood

gan Chen, Xiabin, Zheng, Xirong, Ding, Kai, Zhou, Ziyuan, Zhan, Chang-Guo, Zheng, Fang
Cyhoeddwyd yn J Pharm Biomed Anal (2016)

Metabolic Enzymes of Cocaine Metabolite Benzoylecgonine

gan Chen, Xiabin, Zheng, Xirong, Zhan, Max, Zhou, Ziyuan, Zhan, Chang-Guo, Zheng, Fang
Cyhoeddwyd yn ACS Chem Biol (2016)

Catalytic activities of cocaine hydrolases against the most toxic cocaine metabolite norcocaethylene

gan Zheng, Xirong, Chen, Xiabin, Zhang, Ting, Zhan, Max, Zhan, Chang-Guo, Zheng, Fang
Cyhoeddwyd yn Org Biomol Chem (2020)

Clinical Potential of an Enzyme-based Novel Therapy for Cocaine Overdose

gan Zhang, Ting, Zheng, Xirong, Zhou, Ziyuan, Chen, Xiabin, Jin, Zhenyu, Deng, Jing, Zhan, Chang-Guo, Zheng, Fang
Cyhoeddwyd yn Sci Rep (2017)

Development of a Long-acting Fc-fused Cocaine Hydrolase with Improved Yield of Protein Expression

gan Chen, Xiabin, Deng, Jing, Zheng, Xirong, Zhang, Jinling, Zhou, Ziyuan, Wei, Huimei, Zhan, Chang-Guo, Zheng, Fang
Cyhoeddwyd yn Chem Biol Interact (2019)

Effectiveness of a Cocaine Hydrolase for Cocaine Toxicity Treatment in Male and Female Rats

gan Zheng, Xirong, Zhou, Ziyuan, Zhang, Ting, Jin, Zhenyu, Chen, Xiabin, Deng, Jing, Zhan, Chang-Guo, Zheng, Fang
Cyhoeddwyd yn AAPS J (2017)

Bench‐to‐bedside translation of chimeric antigen receptor (CAR) T cells using a multiscale systems pharmacokinetic‐pharmacodynamic model: A case study with anti‐BCMA CAR‐T...

gan Singh, Aman P., Chen, Wenbo, Zheng, Xirong, Mody, Hardik, Carpenter, Thomas J., Zong, Alice, Heald, Donald L.
Cyhoeddwyd yn CPT Pharmacometrics Syst Pharmacol (2021)

Development of a novel prostate apoptosis response-4 (Par-4) protein entity with an extended duration of action for therapeutic treatment of cancer

gan Kim, Kyungbo, Araujo, Pereira, Hebbar, Nikhil, Zhou, Ziyuan, Zheng, Xirong, Zheng, Fang, Rangnekar, Vivek M, Zhan, Chang-Guo
Cyhoeddwyd yn Protein Eng Des Sel (2019)

Kinetic Characterization of a Cocaine Hydrolase Engineered from Mouse Butyrylcholinesterase

gan Chen, Xiabin, Huang, Xiaoqin, Geng, Liyi, Xue, Liu, Hou, Shurong, Zheng, Xirong, Brimijoin, Stephen, Zheng, Fang, Zhan, Chang-Guo
Cyhoeddwyd yn Biochem J (2015)

Design, synthesis, and discovery of 5-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones and related derivatives as novel inhibitors of mPGES-1

gan Ding, Kai, Zhou, Ziyuan, Zhou, Shuo, Yuan, Yaxia, Kim, Kyungbo, Zhang, Ting, Zheng, Xirong, Zheng, Fang, Zhan, Chang-Guo
Cyhoeddwyd yn Bioorg Med Chem Lett (2018)

Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model

gan Singh, Aman P., Zheng, Xirong, Lin-Schmidt, Xiefan, Chen, Wenbo, Carpenter, Thomas J., Zong, Alice, Wang, Weirong, Heald, Donald L.
Cyhoeddwyd yn MAbs (2019)

Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs

gan Ding, Kai, Zhou, Ziyuan, Hou, Shurong, Yuan, Yaxia, Zhou, Shuo, Zheng, Xirong, Chen, Jianzhong, Loftin, Charles, Zheng, Fang, Zhan, Chang-Guo
Cyhoeddwyd yn Sci Rep (2018)

Model-based Cellular Kinetic Analysis of Chimeric Antigen Receptor-T Cells in Humans

gan Liu, Can, Ayyar, Vivaswath S., Zheng, Xirong, Chen, Wenbo, Zheng, Songmao, Mody, Hardik, Wang, Weirong, Heald, Donald, Singh, Aman P., Cao, Yanguang
Cyhoeddwyd yn Clin Pharmacol Ther (2020)

Development of Fc-fused Cocaine Hydrolase for Cocaine Addiction Treatment: Catalytic and Pharmacokinetic Properties

gan Chen, Xiabin, Deng, Jing, Cui, Wenpeng, Hou, Shurong, Zhang, Jinling, Zheng, Xirong, Ding, Xin, Wei, Huimei, Zhou, Ziyuan, Kim, Kyungbo, Zhan, Chang-Guo, Zheng, Fang
Cyhoeddwyd yn AAPS J (2018)