In vivo characterization of toxicity of norcocaethylene and norcocaine identified as the most toxic cocaine metabolites in male mice

অনুযায়ী Zheng, Xirong, Shang, Linyue, Zhan, Chang-Guo, Zheng, Fang
প্রকাশিত Drug Alcohol Depend (2019)

Kinetic characterization of human butyrylcholinesterase mutants for hydrolysis of cocaethylene

অনুযায়ী Hou, Shurong, Zhan, Max, Zheng, Xirong, Zhan, Chang-Guo, Zheng, Fang
প্রকাশিত Biochem J (2014)

Effects of a cocaine hydrolase engineered from human butyrylcholinesterase on metabolic profile of cocaine in rats

অনুযায়ী Chen, Xiabin, Zheng, Xirong, Zhou, Ziyuan, Zhan, Chang-Guo, Zheng, Fang
প্রকাশিত Chem Biol Interact (2016)

Blocking drug activation as a therapeutic strategy to attenuate acute toxicity and physiological effects of heroin

অনুযায়ী Zhang, Ting, Zheng, Xirong, Kim, Kyungbo, Zheng, Fang, Zhan, Chang-Guo
প্রকাশিত Sci Rep (2018)

Potential anti-obesity effects of a long-acting cocaine hydrolase

অনুযায়ী Zheng, Xirong, Deng, Jing, Zhang, Ting, Yao, Jianzhuang, Zheng, Fang, Zhan, Chang-Guo
প্রকাশিত Chem Biol Interact (2016)

A quantitative LC-MS/MS method for simultaneous determination of cocaine and its metabolites in whole blood

অনুযায়ী Chen, Xiabin, Zheng, Xirong, Ding, Kai, Zhou, Ziyuan, Zhan, Chang-Guo, Zheng, Fang
প্রকাশিত J Pharm Biomed Anal (2016)

Metabolic Enzymes of Cocaine Metabolite Benzoylecgonine

অনুযায়ী Chen, Xiabin, Zheng, Xirong, Zhan, Max, Zhou, Ziyuan, Zhan, Chang-Guo, Zheng, Fang
প্রকাশিত ACS Chem Biol (2016)

Catalytic activities of cocaine hydrolases against the most toxic cocaine metabolite norcocaethylene

অনুযায়ী Zheng, Xirong, Chen, Xiabin, Zhang, Ting, Zhan, Max, Zhan, Chang-Guo, Zheng, Fang
প্রকাশিত Org Biomol Chem (2020)

Clinical Potential of an Enzyme-based Novel Therapy for Cocaine Overdose

অনুযায়ী Zhang, Ting, Zheng, Xirong, Zhou, Ziyuan, Chen, Xiabin, Jin, Zhenyu, Deng, Jing, Zhan, Chang-Guo, Zheng, Fang
প্রকাশিত Sci Rep (2017)

Development of a Long-acting Fc-fused Cocaine Hydrolase with Improved Yield of Protein Expression

অনুযায়ী Chen, Xiabin, Deng, Jing, Zheng, Xirong, Zhang, Jinling, Zhou, Ziyuan, Wei, Huimei, Zhan, Chang-Guo, Zheng, Fang
প্রকাশিত Chem Biol Interact (2019)

Effectiveness of a Cocaine Hydrolase for Cocaine Toxicity Treatment in Male and Female Rats

অনুযায়ী Zheng, Xirong, Zhou, Ziyuan, Zhang, Ting, Jin, Zhenyu, Chen, Xiabin, Deng, Jing, Zhan, Chang-Guo, Zheng, Fang
প্রকাশিত AAPS J (2017)

Bench‐to‐bedside translation of chimeric antigen receptor (CAR) T cells using a multiscale systems pharmacokinetic‐pharmacodynamic model: A case study with anti‐BCMA CAR‐T...

অনুযায়ী Singh, Aman P., Chen, Wenbo, Zheng, Xirong, Mody, Hardik, Carpenter, Thomas J., Zong, Alice, Heald, Donald L.
প্রকাশিত CPT Pharmacometrics Syst Pharmacol (2021)

Development of a novel prostate apoptosis response-4 (Par-4) protein entity with an extended duration of action for therapeutic treatment of cancer

অনুযায়ী Kim, Kyungbo, Araujo, Pereira, Hebbar, Nikhil, Zhou, Ziyuan, Zheng, Xirong, Zheng, Fang, Rangnekar, Vivek M, Zhan, Chang-Guo
প্রকাশিত Protein Eng Des Sel (2019)

Kinetic Characterization of a Cocaine Hydrolase Engineered from Mouse Butyrylcholinesterase

অনুযায়ী Chen, Xiabin, Huang, Xiaoqin, Geng, Liyi, Xue, Liu, Hou, Shurong, Zheng, Xirong, Brimijoin, Stephen, Zheng, Fang, Zhan, Chang-Guo
প্রকাশিত Biochem J (2015)

Design, synthesis, and discovery of 5-((1,3-diphenyl-1H-pyrazol-4-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones and related derivatives as novel inhibitors of mPGES-1

অনুযায়ী Ding, Kai, Zhou, Ziyuan, Zhou, Shuo, Yuan, Yaxia, Kim, Kyungbo, Zhang, Ting, Zheng, Xirong, Zheng, Fang, Zhan, Chang-Guo
প্রকাশিত Bioorg Med Chem Lett (2018)

Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model

অনুযায়ী Singh, Aman P., Zheng, Xirong, Lin-Schmidt, Xiefan, Chen, Wenbo, Carpenter, Thomas J., Zong, Alice, Wang, Weirong, Heald, Donald L.
প্রকাশিত MAbs (2019)

Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs

অনুযায়ী Ding, Kai, Zhou, Ziyuan, Hou, Shurong, Yuan, Yaxia, Zhou, Shuo, Zheng, Xirong, Chen, Jianzhong, Loftin, Charles, Zheng, Fang, Zhan, Chang-Guo
প্রকাশিত Sci Rep (2018)

Model-based Cellular Kinetic Analysis of Chimeric Antigen Receptor-T Cells in Humans

অনুযায়ী Liu, Can, Ayyar, Vivaswath S., Zheng, Xirong, Chen, Wenbo, Zheng, Songmao, Mody, Hardik, Wang, Weirong, Heald, Donald, Singh, Aman P., Cao, Yanguang
প্রকাশিত Clin Pharmacol Ther (2020)

Development of Fc-fused Cocaine Hydrolase for Cocaine Addiction Treatment: Catalytic and Pharmacokinetic Properties

অনুযায়ী Chen, Xiabin, Deng, Jing, Cui, Wenpeng, Hou, Shurong, Zhang, Jinling, Zheng, Xirong, Ding, Xin, Wei, Huimei, Zhou, Ziyuan, Kim, Kyungbo, Zhan, Chang-Guo, Zheng, Fang
প্রকাশিত AAPS J (2018)