Protein tyrosine phosphatases as potential therapeutic targets

Por He, Rong-jun, Yu, Zhi-hong, Zhang, Ruo-yu, Zhang, Zhong-yin
Publicado em 2014

Therapeutic Targeting of Oncogenic Tyrosine Phosphatases

Por Frankson, Rochelle, Yu, Zhi-Hong, Bai, Yunpeng, Li, Qinglin, Zhang, Ruo-Yu, Zhang, Zhong-Yin
Publicado no Cancer Res (2017)

Hydroxyindole Carboxylic Acid-Based Inhibitors for Receptor-Type Protein Tyrosine Protein Phosphatase Beta

Por Zeng, Li-Fan, Zhang, Ruo-Yu, Bai, Yunpeng, Wu, Li, Gunawan, Andrea M., Zhang, Zhong-Yin
Publicado em 2014

Cefsulodin Inspired Potent and Selective Inhibitors of mPTPB, a Virulent Phosphatase from Mycobacterium tuberculosis

Por He, Rongjun, Yu, Zhi-Hong, Zhang, Ruo-Yu, Wu, Li, Gunawan, Andrea M., Zhang, Zhong-Yin
Publicado no ACS Med Chem Lett (2015)

Inhibition of low molecular weight protein tyrosine phosphatase by an induced-fit mechanism

Por He, Rongjun, Wang, Jifeng, Yu, Zhi-Hong, Zhang, Ruo-Yu, Liu, Sijiu, Wu, Li, Zhang, Zhong-Yin
Publicado no J Med Chem (2016)

Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2

Por Zhang, Ruo-Yu, Yu, Zhi-Hong, Chen, Lan, Walls, Chad D., Zhang, Sheng, Wu, Li, Zhang, Zhong-Yin
Publicado no J Biol Chem (2020)

Highly Potent and Selective N-Aryl Oxamic Acid-Based Inhibitors for Mycobacterium tuberculosis Protein Tyrosine Phosphatase B

Por Ruddraraju, Kasi Viswanatharaju, Aggarwal, Devesh, Niu, Congwei, Baker, Erica Anne, Zhang, Ruo-yu, Wu, Li, Zhang, Zhong-Yin
Publicado no J Med Chem (2020)

Loss of AMP-Activated Protein Kinase-α2 Impairs the Insulin-Sensitizing Effect of Calorie Restriction in Skeletal Muscle

Por Wang, Pei, Zhang, Ruo-Yu, Song, Jie, Guan, Yun-Feng, Xu, Tian-Ying, Du, Hui, Viollet, Benoit, Miao, Chao-Yu
Publicado em 2012

Molecular Basis of Gain-of-Function LEOPARD Syndrome-Associated SHP2 Mutations

Por Yu, Zhi-Hong, Zhang, Ruo-Yu, Walls, Chad D., Chen, Lan, Zhang, Sheng, Wu, Li, Liu, Sijiu, Zhang, Zhong-Yin
Publicado em 2014

Novel anticancer agents based on targeting the trimer interface of the PRL phosphatase

Por Bai, Yunpeng, Yu, Zhi-Hong, Liu, Sijiu, Zhang, Lujuan, Zhang, Ruo-Yu, Zeng, Li-Fan, Zhang, Sheng, Zhang, Zhong-Yin
Publicado no Cancer Res (2016)

SHP2 phosphatase as a novel therapeutic target for melanoma treatment

Por Zhang, Ruo-Yu, Yu, Zhi-Hong, Zeng, Lifan, Zhang, Sheng, Bai, Yunpeng, Miao, Jinmin, Chen, Lan, Xie, Jingwu, Zhang, Zhong-Yin
Publicado no Oncotarget (2016)

Quinic Acid-Conjugated Nanoparticles Enhance Drug Delivery to Solid Tumors via Interactions with Endothelial Selectins

Por Xu, Jun, Seung-Young Lee, Steve, Seo, Howon, Pang, Liang, Jun, Yearin, Zhang, Ruo-Yu, Zhang, Zhong-Yin, Kim, Pilhan, Lee, Wooin, Kron, Stephen J., Yeo, Yoon
Publicado no Small (2018)

Discovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribosyltransferase

Por Xu, Tian-Ying, Zhang, Sai-Long, Dong, Guo-Qiang, Liu, Xin-Zhu, Wang, Xia, Lv, Xiao-Qun, Qian, Qi-Jun, Zhang, Ruo-Yu, Sheng, Chun-Quan, Miao, Chao-Yu
Publicado no Sci Rep (2015)

Therapeutic Potential of Targeting the Oncogenic SHP2 Phosphatase

Por Zeng, Li-Fan, Zhang, Ruo-Yu, Yu, Zhi-Hong, Li, Sijiu, Wu, Li, Gunawan, Andrea M., Lane, Brandon S., Mali, Raghuveer S., Li, Xingjun, Chan, Rebecca J., Kapur, Reuben, Wells, Clark D., Zhang, Zhong-Yin
Publicado em 2014

Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors

Por He, Rongjun, Yu, Zhi-Hong, Zhang, Ruo-Yu, Wu, Li, Gunawan, Andrea M., Lane, Brandon S., Shim, Joong S., Zeng, Li-Fan, He, Yantao, Chen, Lan, Wells, Clark D., Liu, Jun O., Zhang, Zhong-Yin
Publicado no ACS Med Chem Lett (2015)