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Highly Potent and Selective N-Aryl Oxamic Acid-Based Inhibitors for Mycobacterium tuberculosis Protein Tyrosine Phosphatase B

Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis (Mtb). Mtb protein tyrosine phosphatase B (mPTPB) is a virulence factor required for Mtb survival in host macrophages. Consequently, mPTPB represents an exciting target for tuberculosis treatment. Here, we ident...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Ruddraraju, Kasi Viswanatharaju, Aggarwal, Devesh, Niu, Congwei, Baker, Erica Anne, Zhang, Ruo-yu, Wu, Li, Zhang, Zhong-Yin
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7688068/
https://ncbi.nlm.nih.gov/pubmed/32787087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00302
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