Cefsulodin Inspired Potent and Selective Inhibitors of mPTPB, a Virulent Phosphatase from Mycobacterium tuberculosis

[Image: see text] mPTPB is a virulent phosphatase from Mycobacterium tuberculosis and a promising therapeutic target for tuberculosis. To facilitate mPTPB-based drug discovery, we identified α-sulfophenylacetic amide (SPAA) from cefsulodin, a third generation β-lactam cephalosporin antibiotic, as a...

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Vydáno v:ACS Med Chem Lett
Hlavní autoři: He, Rongjun, Yu, Zhi-Hong, Zhang, Ruo-Yu, Wu, Li, Gunawan, Andrea M., Zhang, Zhong-Yin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2015
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4677373/
https://ncbi.nlm.nih.gov/pubmed/26713110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00373
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