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Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2
The protein-tyrosine phosphatase SHP2 is an allosteric enzyme critical for cellular events downstream of growth factor receptors. Mutations in the SHP2 gene have been linked to many different types of human diseases, including developmental disorders, leukemia, and solid tumors. Unlike most SHP2-act...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7196634/ https://ncbi.nlm.nih.gov/pubmed/32188694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010274 |
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