Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations

SHP2 is an allosteric phosphatase essential for growth factor-mediated Ras activation. Germ-line mutations in SHP2 cause clinically similar LEOPARD and Noonan syndromes, two of several autosomal-dominant conditions characterized by gain-of-function mutations in the Ras pathway. Interestingly, Noonan...

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Main Authors: Yu, Zhi-Hong, Xu, Jie, Walls, Chad D., Chen, Lan, Zhang, Sheng, Zhang, Ruoyu, Wu, Li, Wang, Lina, Liu, Sijiu, Zhang, Zhong-Yin
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624429/
https://ncbi.nlm.nih.gov/pubmed/23457302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.450023
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