Small molecule tools for functional interrogation of protein tyrosine phosphatases

por He, Rongjun, Zeng, Li-Fan, He, Yantao, Zhang, Sheng, Zhang, Zhong-Yin
Publicado 2012

Targeting SHP2 for EGFR Inhibitor Resistant Non-Small Cell Lung Carcinoma

por Xu, Jie, Zeng, Li-Fan, Shen, Weihua, Turchi, John J., Zhang, Zhong-Yin
Publicado 2013

Bicyclic benzofuran and indole-based salicylic acids as protein tyrosine phosphatase inhibitors

por He, Yantao, Zeng, Li-Fan, Yu, Zhi-Hong, He, Rongjun, Liu, Sijiu, Zhang, Zhong-Yin
Publicado 2011

Organocatalytic Multicomponent Reaction for the Acquisition of a Selective Inhibitor of mPTPB, a Virulence Factor of Tuberculosis

por He, Rongjun, Zeng, Li-Fan, He, Yantao, Wu, Li, Gunawan, Andrea Michelle, Zhang, Zhong-Yin
Publicado 2013

Hydroxyindole Carboxylic Acid-Based Inhibitors for Receptor-Type Protein Tyrosine Protein Phosphatase Beta

por Zeng, Li-Fan, Zhang, Ruo-Yu, Bai, Yunpeng, Wu, Li, Gunawan, Andrea M., Zhang, Zhong-Yin
Publicado 2014

Oncogenic KIT-induced aggressive systemic mastocytosis requires SHP2/PTPN11 phosphatase for disease progression in mice

por Sharma, Namit, Everingham, Stephanie, Zeng, Li-Fan, Zhang, Zhong-Yin, Kapur, Reuben, Craig, Andrew W.B.
Publicado 2014

A facile hydroxyindole carboxylic acid-based focused library approach for potent and selective inhibitors of Mycobacterium protein tyrosine phosphatase B

por Zeng, Li-Fan, Xu, Jie, He, Yantao, He, Rongjun, Wu, Li, Gunawan, Andrea M., Zhang, Zhong-Yin
Publicado 2013

Targeting Inactive Enzyme Conformation: Aryl Diketoacid Derivatives as a New Class of PTP1B Inhibitors

por Liu, Sijiu, Zeng, Li-Fan, Wu, Li, Yu, Xiao, Xue, Ting, Gunawan, Andrea M., Ya-Qiu, Long, Zhang, Zhong-Yin
Publicado 2008

Novel anticancer agents based on targeting the trimer interface of the PRL phosphatase

por Bai, Yunpeng, Yu, Zhi-Hong, Liu, Sijiu, Zhang, Lujuan, Zhang, Ruo-Yu, Zeng, Li-Fan, Zhang, Sheng, Zhang, Zhong-Yin
Publicado en Cancer Res (2016)

Double Click Reaction for the Acquisition of a Highly Potent and Selective mPTPB Inhibitor

por He, Rongjun, Yu, Zhihong, He, Yantao, Zeng, Li-Fan, Xu, Jie, Wu, Li, Gunawan, Andrea M., Wang, Lina, Jiang, Zhong-Xing, Zhang, Zhong-Yin
Publicado 2010

Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus

por Wang, Jianxun, Mizui, Masayuki, Zeng, Li-Fan, Bronson, Roderick, Finnell, Michele, Terhorst, Cox, Kyttaris, Vasileios C., Tsokos, George C., Zhang, Zhong-Yin, Kontaridis, Maria I.
Publicado en J Clin Invest (2016)

Design of HIV-1 Integrase Inhibitors Targeting the Catalytic Domain as Well as Its Interaction with LEDGF/p75: A Scaffold Hopping Approach Using Salicylate and Catechol Groups

por Fan, Xing, Zhang, Feng-Hua, Al-Safi, Rasha I., Zeng, Li-Fan, Shabaik, Yumna, Debnath, Bikash, Sanchez, Tino W., Odde, Srinivas, Neamati, Nouri, Long, Ya-Qiu
Publicado 2011

SH2 Domain-Containing Phosphatase 2 Is a Critical Regulator of Connective Tissue Mast Cell Survival and Homeostasis in Mice

por Sharma, Namit, Kumar, Vijay, Everingham, Stephanie, Mali, Raghuveer Singh, Kapur, Reuben, Zeng, Li-Fan, Zhang, Zhong-Yin, Feng, Gen-Sheng, Hartmann, Karin, Roers, Axel, Craig, Andrew W. B.
Publicado 2012

Therapeutic Potential of Targeting the Oncogenic SHP2 Phosphatase

por Zeng, Li-Fan, Zhang, Ruo-Yu, Yu, Zhi-Hong, Li, Sijiu, Wu, Li, Gunawan, Andrea M., Lane, Brandon S., Mali, Raghuveer S., Li, Xingjun, Chan, Rebecca J., Kapur, Reuben, Wells, Clark D., Zhang, Zhong-Yin
Publicado 2014

Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors

por He, Rongjun, Yu, Zhi-Hong, Zhang, Ruo-Yu, Wu, Li, Gunawan, Andrea M., Lane, Brandon S., Shim, Joong S., Zeng, Li-Fan, He, Yantao, Chen, Lan, Wells, Clark D., Liu, Jun O., Zhang, Zhong-Yin
Publicado en ACS Med Chem Lett (2015)

Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation

por Maeshima, Keisuke, Stanford, Stephanie M., Hammaker, Deepa, Sacchetti, Cristiano, Zeng, Li-fan, Ai, Rizi, Zhang, Vida, Boyle, David L., Aleman Muench, German R., Feng, Gen-Sheng, Whitaker, John W., Zhang, Zhong-Yin, Wang, Wei, Bottini, Nunzio, Firestein, Gary S.
Publicado en JCI Insight (2016)

Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT

por Mali, Raghuveer Singh, Ma, Peilin, Zeng, Li-Fan, Martin, Holly, Ramdas, Baskar, He, Yantao, Sims, Emily, Nabinger, Sarah, Ghosh, Joydeep, Sharma, Namit, Munugalavadla, Veerendra, Chatterjee, Anindya, Li, Shuo, Sandusky, George, Craig, Andrew W., Bunting, Kevin D., Feng, Gen-Sheng, Chan, Rebecca J., Zhang, Zhong-Yin, Kapur, Reuben
Publicado 2012