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Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a devastating multisystemic autoimmune disorder. However, the molecular mechanisms underlying its pathogenesis remain elusive. Some patients with Noonan syndrome, a congenital disorder predominantly caused by gain-of-function mutations in the protein tyrosine ph...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4887187/ https://ncbi.nlm.nih.gov/pubmed/27183387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI87037 |
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