The 5-substituted piperazine as a novel secondary pharmacophore greatly improving the physical properties of urea-based inhibitors of soluble epoxide hydrolase

Por Li, Hui-Yuan, Jin, Yi, Morisseau, Christophe, Hammock, Bruce D., Long, Ya-Qiu
Publicado em 2006

Structure-based optimization of the piperazino-containing 1,3-disubstituted ureas affording sub-nanomolar inhibitors of soluble epoxide hydrolase

Por Huang, Shao-Xu, Cao, Bin, Morisseau, Christophe, Jin, Yi, Hammock, Bruce D., Long, Ya-Qiu
Publicado em 2012

Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacok...

Por Huang, Shao-Xu, Li, Hui-Yuan, Liu, Jun-Yan, Morisseau, Christophe, Hammock, Bruce D., Long, Ya-Qiu
Publicado em 2010

The Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton

Por Randazzo, Paul A., Andrade, Josefa, Miura, Koichi, Brown, Megan T., Long, Ya-Qiu, Stauffer, Stacey, Roller, Peter, Cooper, Jonathan A.
Publicado em 2000

Design of HIV-1 Integrase Inhibitors Targeting the Catalytic Domain as Well as Its Interaction with LEDGF/p75: A Scaffold Hopping Approach Using Salicylate and Catechol Groups

Por Fan, Xing, Zhang, Feng-Hua, Al-Safi, Rasha I., Zeng, Li-Fan, Shabaik, Yumna, Debnath, Bikash, Sanchez, Tino W., Odde, Srinivas, Neamati, Nouri, Long, Ya-Qiu
Publicado em 2011