Structure-based optimization of the piperazino-containing 1,3-disubstituted ureas affording sub-nanomolar inhibitors of soluble epoxide hydrolase

Por Huang, Shao-Xu, Cao, Bin, Morisseau, Christophe, Jin, Yi, Hammock, Bruce D., Long, Ya-Qiu
Publicado em 2012

Incorporation of piperazino functionality into 1,3-disubstituted urea as the tertiary pharmacophore affording potent inhibitors of soluble epoxide hydrolase with improved pharmacok...

Por Huang, Shao-Xu, Li, Hui-Yuan, Liu, Jun-Yan, Morisseau, Christophe, Hammock, Bruce D., Long, Ya-Qiu
Publicado em 2010

Anti-AIDS Agents 72. Bioisosteres (7-carbon-DCKs) of the potent anti-HIV lead DCK

Por Wang, Yang, Huang, Shao-Xu, Xia, Peng, Xia, Yi, Yang, Zheng-Yu, Kilgore, Nicole, Morris-Natschke, Susan L., Lee, Kuo-Hsiung
Publicado em 2007

Design of Cell-Permeable Stapled-Peptides as HIV-1 Integrase Inhibitors

Por Long, Ya-Qiu, Huang, Shao-Xu, Zawahir, Zahrah, Xu, Zhong-Liang, Li, Huiyuan, Sanchez, Tino W., Zhi, Ying, De Houwer, Stephanie, Christ, Frauke, Debyser, Zeger, Neamati, Nouri
Publicado no J Med Chem (2013)