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Discovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribosyltransferase
Nicotinamide phosphoribosyltransferase (NAMPT) is a promising anticancer target. Using high throughput screening system targeting NAMPT, we obtained a potent NAMPT inhibitor MS0 (China Patent ZL201110447488.9) with excellent in vitro activity (IC50 = 9.87 ± 1.15nM) and anti-proliferative activity ag...
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| Izdano u: | Sci Rep |
|---|---|
| Glavni autori: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4603696/ https://ncbi.nlm.nih.gov/pubmed/26040985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10043 |
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