Discovery and characterization of novel small-molecule inhibitors targeting nicotinamide phosphoribosyltransferase

Nicotinamide phosphoribosyltransferase (NAMPT) is a promising anticancer target. Using high throughput screening system targeting NAMPT, we obtained a potent NAMPT inhibitor MS0 (China Patent ZL201110447488.9) with excellent in vitro activity (IC50 = 9.87 ± 1.15nM) and anti-proliferative activity ag...

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Udgivet i:Sci Rep
Main Authors: Xu, Tian-Ying, Zhang, Sai-Long, Dong, Guo-Qiang, Liu, Xin-Zhu, Wang, Xia, Lv, Xiao-Qun, Qian, Qi-Jun, Zhang, Ruo-Yu, Sheng, Chun-Quan, Miao, Chao-Yu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4603696/
https://ncbi.nlm.nih.gov/pubmed/26040985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep10043
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