Population pharmacokinetic analysis of sifalimumab from a clinical phase IIb trial in systemic lupus erythematosus patients

Por Zheng, Bo, Yu, Xiang‐Qing, Greth, Warren, Robbie, Gabriel J.
Publicado no Br J Clin Pharmacol (2016)

pH-dependent Binding Engineering Reveals an FcRn Affinity Threshold That Governs IgG Recycling

Por Borrok, M. Jack, Wu, Yanli, Beyaz, Nurten, Yu, Xiang-Qing, Oganesyan, Vaheh, Dall'Acqua, William F., Tsui, Ping
Publicado no J Biol Chem (2015)

Safety, Tolerability, and Pharmacokinetics of MEDI4893, an Investigational, Extended-Half-Life, Anti-Staphylococcus aureus Alpha-Toxin Human Monoclonal Antibody, in Healthy Adults

Por Yu, Xiang-Qing, Robbie, Gabriel J., Wu, Yuling, Esser, Mark T., Jensen, Kathryn, Schwartz, Howard I., Bellamy, Terramika, Hernandez-Illas, Martha, Jafri, Hasan S.
Publicado no Antimicrob Agents Chemother (2016)

Generation and Characterization of an IgG4 Monomeric Fc Platform

Por Shan, Lu, Colazet, Magali, Rosenthal, Kim L., Yu, Xiang-Qing, Bee, Jared S., Ferguson, Andrew, Damschroder, Melissa M., Wu, Herren, Dall’Acqua, William F., Tsui, Ping, Oganesyan, Vaheh
Publicado no PLoS One (2016)

Insertion of scFv into the hinge domain of full-length IgG1 monoclonal antibody results in tetravalent bispecific molecule with robust properties

Por Bezabeh, Binyam, Fleming, Ryan, Fazenbaker, Christine, Zhong, Haihong, Coffman, Karen, Yu, Xiang-Qing, Leow, Ching Ching, Gibson, Nerea, Wilson, Susan, Stover, C. Kendall, Wu, Herren, Gao, Changshou, Dimasi, Nazzareno
Publicado no MAbs (2016)

Phase I Dose-Escalation Study of MEDI-573, a Bispecific, Antiligand Monoclonal Antibody against IGFI and IGFII, in Patients with Advanced Solid Tumors

Por Haluska, Paul, Menefee, Michael, Plimack, Elizabeth R., Rosenberg, Jonathan, Northfelt, Donald, LaVallee, Theresa, Shi, Li, Yu, Xiang-Qing, Burke, Patricia, Huang, Jaiqi, Viner, Jaye, McDevitt, Jennifer, LoRusso, Patricia
Publicado no Clin Cancer Res (2014)

Improving target cell specificity using a novel monovalent bispecific IgG design

Por Mazor, Yariv, Oganesyan, Vaheh, Yang, Chunning, Hansen, Anna, Wang, Jihong, Liu, Hongji, Sachsenmeier, Kris, Carlson, Marcia, Gadre, Dhanesh V, Borrok, Martin Jack, Yu, Xiang-Qing, Dall’Acqua, William, Wu, Herren, Chowdhury, Partha Sarathi
Publicado no MAbs (2015)

Enhancement of antibody functions through Fc multiplications

Por Wang, Qun, Chen, Yan, Pelletier, Mark, Cvitkovic, Romana, Bonnell, Jessica, Chang, Chien-Ying, Koksal, Adem C., O'Connor, Ellen, Gao, Xizhe, Yu, Xiang-Qing, Wu, Herren, Stover, C. Kendall, Dall'Acqua, William F., Xiao, Xiaodong
Publicado no MAbs (2017)

Critical Role of Alpha-Toxin and Protective Effects of Its Neutralization by a Human Antibody in Acute Bacterial Skin and Skin Structure Infections

Por Le, Vien T. M., Tkaczyk, Christine, Chau, Sally, Rao, Renee L., Dip, Etyene Castro, Pereira-Franchi, Eliane P., Cheng, Lily, Lee, Sally, Koelkebeck, Holly, Hilliard, Jamese J., Yu, Xiang Qing, Datta, Vivekananda, Nguyen, Vien, Weiss, William, Prokai, Laszlo, O'Day, Terrence, Stover, C. Kendall, Sellman, Bret R., Diep, Binh An
Publicado no Antimicrob Agents Chemother (2016)