Phase I Dose-Escalation Study of MEDI-573, a Bispecific, Antiligand Monoclonal Antibody against IGFI and IGFII, in Patients with Advanced Solid Tumors

PURPOSE: This phase I, multicenter, open-label, single-arm, dose-escalation, and dose-expansion study evaluated the safety, tolerability, and antitumor activity of MEDI-573 in adults with advanced solid tumors refractory to standard therapy or for which no standard therapy exists. EXPERIMENTAL DESIG...

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Détails bibliographiques
Publié dans:Clin Cancer Res
Auteurs principaux: Haluska, Paul, Menefee, Michael, Plimack, Elizabeth R., Rosenberg, Jonathan, Northfelt, Donald, LaVallee, Theresa, Shi, Li, Yu, Xiang-Qing, Burke, Patricia, Huang, Jaiqi, Viner, Jaye, McDevitt, Jennifer, LoRusso, Patricia
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4377301/
https://ncbi.nlm.nih.gov/pubmed/25024259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0114
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