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pH-dependent Binding Engineering Reveals an FcRn Affinity Threshold That Governs IgG Recycling
The Fc domain of IgG has been the target of multiple mutational studies aimed at altering the pH-dependent IgG/FcRn interaction to modulate IgG pharmacokinetics. These studies have yielded antibody variants with disparate pharmacokinetic characteristics, ranging from extended in vivo half-life to th...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4326836/ https://ncbi.nlm.nih.gov/pubmed/25538249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.603712 |
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