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Methionine oxidation in human IgG2 Fc decreases binding affinities to protein A and FcRn
Susceptibility of methionine residues to oxidation is a significant issue of protein therapeutics. Methionine oxidation may limit the product's clinical efficacy or stability. We have studied kinetics of methionine oxidation in the Fc portion of the human IgG2 and its impact on the interaction...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Wiley Subscription Services, Inc., A Wiley Company
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2708056/ https://ncbi.nlm.nih.gov/pubmed/19165723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.45 |
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