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The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity
The neonatal Fc receptor (FcRn) is expressed by cells of epithelial, endothelial and myeloid lineages and performs multiple roles in adaptive immunity. Characterizing the FcRn/IgG interaction is fundamental to designing therapeutic antibodies because IgGs with moderately increased binding affinities...
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| Udgivet i: | MAbs |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Taylor & Francis
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4622529/ https://ncbi.nlm.nih.gov/pubmed/25658443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1008353 |
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