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The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity

The neonatal Fc receptor (FcRn) is expressed by cells of epithelial, endothelial and myeloid lineages and performs multiple roles in adaptive immunity. Characterizing the FcRn/IgG interaction is fundamental to designing therapeutic antibodies because IgGs with moderately increased binding affinities...

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Bibliografiske detaljer
Udgivet i:MAbs
Main Authors: Abdiche, Yasmina Noubia, Yeung, Yik Andy, Chaparro-Riggers, Javier, Barman, Ishita, Strop, Pavel, Chin, Sherman Michael, Pham, Amber, Bolton, Gary, McDonough, Dan, Lindquist, Kevin, Pons, Jaume, Rajpal, Arvind
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622529/
https://ncbi.nlm.nih.gov/pubmed/25658443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1008353
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