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Safety, Tolerability, and Pharmacokinetics of MEDI4893, an Investigational, Extended-Half-Life, Anti-Staphylococcus aureus Alpha-Toxin Human Monoclonal Antibody, in Healthy Adults
MEDI4893 is an investigational immunoglobulin G1(κ) monoclonal antibody that specifically binds to and neutralizes alpha-toxin, a key Staphylococcus aureus virulence factor. A triple-amino-acid substitution, M252Y/S254T/T256E, was engineered into the MEDI4893 Fc region to extend its serum half-life....
Sparad:
I publikationen: | Antimicrob Agents Chemother |
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Huvudupphovsmän: | , , , , , , , , |
Materialtyp: | Artigo |
Språk: | Inglês |
Publicerad: |
American Society for Microbiology
2016
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Ämnen: | |
Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5192133/ https://ncbi.nlm.nih.gov/pubmed/27795368 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01020-16 |
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