Safety, Tolerability, and Pharmacokinetics of MEDI4893, an Investigational, Extended-Half-Life, Anti-Staphylococcus aureus Alpha-Toxin Human Monoclonal Antibody, in Healthy Adults

MEDI4893 is an investigational immunoglobulin G1(κ) monoclonal antibody that specifically binds to and neutralizes alpha-toxin, a key Staphylococcus aureus virulence factor. A triple-amino-acid substitution, M252Y/S254T/T256E, was engineered into the MEDI4893 Fc region to extend its serum half-life....

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Yu, Xiang-Qing, Robbie, Gabriel J., Wu, Yuling, Esser, Mark T., Jensen, Kathryn, Schwartz, Howard I., Bellamy, Terramika, Hernandez-Illas, Martha, Jafri, Hasan S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Clinical Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192133/
https://ncbi.nlm.nih.gov/pubmed/27795368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01020-16
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