Improving target cell specificity using a novel monovalent bispecific IgG design

Monovalent bispecific IgGs cater to a distinct set of mechanisms of action but are difficult to engineer and manufacture because of complexities associated with correct heavy and light chain pairing. We have created a novel design, “DuetMab,” for efficient production of these molecules. The platform...

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Bibliografiska uppgifter
I publikationen:MAbs
Huvudupphovsmän: Mazor, Yariv, Oganesyan, Vaheh, Yang, Chunning, Hansen, Anna, Wang, Jihong, Liu, Hongji, Sachsenmeier, Kris, Carlson, Marcia, Gadre, Dhanesh V, Borrok, Martin Jack, Yu, Xiang-Qing, Dall’Acqua, William, Wu, Herren, Chowdhury, Partha Sarathi
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2015
Ämnen:
Reports
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622537/
https://ncbi.nlm.nih.gov/pubmed/25621507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2015.1007816
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