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Enhanced tumor-targeting selectivity by modulating bispecific antibody binding affinity and format valence
Bispecific antibodies are considered attractive bio-therapeutic agents owing to their ability to target two distinct disease mediators. Cross-arm avidity targeting of antigen double-positive cancer cells over single-positive normal tissue is believed to enhance the therapeutic efficacy, restrict maj...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5220356/ https://ncbi.nlm.nih.gov/pubmed/28067257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40098 |
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