Regulation of antibody-mediated complement-dependent cytotoxicity by modulating the intrinsic affinity and binding valency of IgG for target antigen

Complement-dependent cytotoxicity (CDC) is a potent effector mechanism, engaging both innate and adaptive immunity. Although strategies to improve the CDC activity of antibody therapeutics have primarily focused on enhancing the interaction between the antibody crystallizable fragment (Fc) and the f...

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Vydáno v:MAbs
Hlavní autoři: Wang, Bo, Yang, Chunning, Jin, Xiaofang, Du, Qun, Wu, Herren, Dall’Acqua, William, Mazor, Yariv
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927764/
https://ncbi.nlm.nih.gov/pubmed/31829766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1690959
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