Regulation of antibody-mediated complement-dependent cytotoxicity by modulating the intrinsic affinity and binding valency of IgG for target antigen

Complement-dependent cytotoxicity (CDC) is a potent effector mechanism, engaging both innate and adaptive immunity. Although strategies to improve the CDC activity of antibody therapeutics have primarily focused on enhancing the interaction between the antibody crystallizable fragment (Fc) and the f...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Wang, Bo, Yang, Chunning, Jin, Xiaofang, Du, Qun, Wu, Herren, Dall’Acqua, William, Mazor, Yariv
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927764/
https://ncbi.nlm.nih.gov/pubmed/31829766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1690959
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