Regulation of antibody-mediated complement-dependent cytotoxicity by modulating the intrinsic affinity and binding valency of IgG for target antigen

Complement-dependent cytotoxicity (CDC) is a potent effector mechanism, engaging both innate and adaptive immunity. Although strategies to improve the CDC activity of antibody therapeutics have primarily focused on enhancing the interaction between the antibody crystallizable fragment (Fc) and the f...

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Publicado en:MAbs
Autores principales: Wang, Bo, Yang, Chunning, Jin, Xiaofang, Du, Qun, Wu, Herren, Dall’Acqua, William, Mazor, Yariv
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2019
Materias:
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927764/
https://ncbi.nlm.nih.gov/pubmed/31829766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1690959
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