Enhancement of Immune Effector Functions by Modulating IgG’s Intrinsic Affinity for Target Antigen

Antibody-mediated immune effector functions play an essential role in the anti-tumor efficacy of many therapeutic mAbs. While much of the effort to improve effector potency has focused on augmenting the interaction between the antibody-Fc and activating Fc-receptors expressed on immune cells, the ro...

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Udgivet i:PLoS One
Main Authors: Mazor, Yariv, Yang, Chunning, Borrok, M. Jack, Ayriss, Joanne, Aherne, Karen, Wu, Herren, Dall’Acqua, William F.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4913924/
https://ncbi.nlm.nih.gov/pubmed/27322177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0157788
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