Standard Opioid Agonists Activate Heteromeric Opioid Receptors: Evidence for Morphine and [d-Ala(2)-MePhe(4)-Glyol(5)]Enkephalin as Selective μ−δ Agonists

door Yekkirala, Ajay S., Kalyuzhny, Alexander E., Portoghese, Philip S.
Gepubliceerd in 2009

An immunocytochemical-derived correlate for evaluating the bridging of heteromeric mu-delta opioid protomers by bivalent ligands

door Yekkirala, Ajay S., Kalyuzhny, Alexander E, Portoghese, Philip S.
Gepubliceerd in ACS Chem Biol (2013)

A bivalent ligand (KMN-21) antagonist for μ/κ heterodimeric opioid receptors

door Zhang, Shijun, Yekkirala, Ajay, Tang, Ye, Portoghese, Philip S.
Gepubliceerd in Bioorg Med Chem Lett (2009)

Basic/translational Development of Forthcoming Opioid and Non-Opioid Targeted Pain Therapeutics

door Knezevic, Nebojsa Nick, Yekkirala, Ajay, Yaksh, Tony L.
Gepubliceerd in Anesth Analg (2017)

Naloxone acts as a potent analgesic in transgenic mouse models of sickle cell anemia

door Lunzer, Mary M., Yekkirala, Ajay, Hebbel, Robert P., Portoghese, Philip S.
Gepubliceerd in 2007

Breaking barriers to novel analgesic drug development

door Yekkirala, Ajay S, Roberson, David P, Bean, Bruce P., Woolf, Clifford J.
Gepubliceerd in Nat Rev Drug Discov (2017)

Breaking barriers to novel analgesic drug development

door Yekkirala, Ajay S., Roberson, David P., Bean, Bruce P., Woolf, Clifford J.
Gepubliceerd in Nat Rev Drug Discov (2017)

Clinically Employed Opioid Analgesics Produce Antinociception via μ-δ Opioid Receptor Heteromers in Rhesus Monkeys

door Yekkirala, Ajay S., Banks, Matthew L., Lunzer, Mary M., Negus, Stevens S., Rice, Kenner C., Portoghese, Philip S.
Gepubliceerd in 2012

Bivalent ligands that target mu opioid (MOP) and cannabinoid1 (CB(1)) receptors are potent analgesics devoid of tolerance

door Naour, Morgan Le, Akgün, Eyup, Yekkirala, Ajay, Lunzer, Mary M., Powers, Mike D., Kalyuzhny, Alexander E., Portoghese, Philip S.
Gepubliceerd in 2013

The δ Opioid Receptor Agonist SNC80 Selectively Activates Heteromeric μ–δ Opioid Receptors

door Metcalf, Matthew D., Yekkirala, Ajay S., Powers, Michael D., Kitto, Kelley F., Fairbanks, Carolyn A., Wilcox, George L., Portoghese, Philip S.
Gepubliceerd in 2012

N-naphthoyl-β-naltrexamine (NNTA), a highly selective and potent activator of μ/κ-opioid heteromers

door Yekkirala, Ajay S., Lunzer, Mary M., McCurdy, Christopher R., Powers, Michael D., Kalyuzhny, Alexander E., Roerig, Sandra C., Portoghese, Philip S.
Gepubliceerd in 2011

A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program

door Chandran, Vijayendran, Coppola, Giovanni, Nawabi, Homaira, Omura, Takao, Versano, Revital, Huebner, Eric A., Zhang, Alice, Costigan, Michael, Yekkirala, Ajay, Barrett, Lee, Blesch, Armin, Michaelevski, Izhak, Davis-Turak, Jeremy, Gao, Fuying, Langfelder, Peter, Horvath, Steve, He, Zhigang, Benowitz, Larry, Fainzilber, Mike, Tuszynski, Mark, Woolf, Clifford J., Geschwind, Daniel H.
Gepubliceerd in Neuron (2016)

Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain

door Sisignano, Marco, Angioni, Carlo, Park, Chul-Kyu, Meyer Dos Santos, Sascha, Jordan, Holger, Kuzikov, Maria, Liu, Di, Zinn, Sebastian, Hohman, Stephan W., Schreiber, Yannick, Zimmer, Béla, Schmidt, Mike, Lu, Ruirui, Suo, Jing, Zhang, Dong-Dong, Schäfer, Stephan M. G., Hofmann, Martine, Yekkirala, Ajay S., de Bruin, Natasja, Parnham, Michael J., Woolf, Clifford J., Ji, Ru-Rong, Scholich, Klaus, Geisslinger, Gerd
Gepubliceerd in Proc Natl Acad Sci U S A (2016)