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Bivalent ligands that target mu opioid (MOP) and cannabinoid1 (CB(1)) receptors are potent analgesics devoid of tolerance
Given that mu opioid (MOP) and canabinoid (CB(1)) receptors are co-localized in various regions of the CNS and have been reported to associate as heteromer (MOP-CB(1)) in cultured cells has raised the possibility of functional, endogenous MOP-CB(1) in nociception and other pharmacologic effects. As...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3849126/ https://ncbi.nlm.nih.gov/pubmed/23734559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4005219 |
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