Bivalent ligands that target mu opioid (MOP) and cannabinoid1 (CB(1)) receptors are potent analgesics devoid of tolerance

Given that mu opioid (MOP) and canabinoid (CB(1)) receptors are co-localized in various regions of the CNS and have been reported to associate as heteromer (MOP-CB(1)) in cultured cells has raised the possibility of functional, endogenous MOP-CB(1) in nociception and other pharmacologic effects. As...

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Main Authors: Naour, Morgan Le, Akgün, Eyup, Yekkirala, Ajay, Lunzer, Mary M., Powers, Mike D., Kalyuzhny, Alexander E., Portoghese, Philip S.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3849126/
https://ncbi.nlm.nih.gov/pubmed/23734559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4005219
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