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The bivalent ligand, MMG22, reduces neuropathic pain after nerve injury without the side effects of traditional opioids

Functional interactions between the mu opioid receptor (MOR) and the metabotropic glutamate receptor 5 (mGluR(5)) in pain and analgesia have been well established. MMG22 is a bivalent ligand containing MOR agonist (oxymorphamine) and mGluR(5) antagonist (MPEP) pharmacophores tethered by a 22-atom li...

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Detalhes bibliográficos
Publicado no:Pain
Main Authors: Speltz, Rebecca, Lunzer, Mary M., Shueb, Sarah S., Akgün, Eyup, Reed, Rachelle, Kalyuzhny, Alex, Portoghese, Philip S., Simone, Donald A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7606301/
https://ncbi.nlm.nih.gov/pubmed/32345918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000001902
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