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The bivalent ligand MCC22 potently attenuates nociception in a murine model of sickle cell disease

Sickle cell disease (SCD) is a chronic inflammatory disorder accompanied by chronic pain. In addition to ongoing pain and hyperalgesia, vaso-occlusive crises-induced pain can be chronic or episodic. Since analgesics typically used to treat pain are not very effective in SCD, opioids, including morph...

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Detalhes bibliográficos
Publicado no:Pain
Main Authors: Cataldo, Giuseppe, Lunzer, Mary M., Olson, Julie K., Akgün, Eyup, Belcher, John D., Vercellotti, Gregory M., Portoghese, Philip S., Simone, Donald A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008209/
https://ncbi.nlm.nih.gov/pubmed/29578946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000001225
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