Modulation of Cell Surface Expression of Nonactivated Cholecystokinin Receptors Using Bivalent Ligand-Induced Internalization

Por Harikumar, Kaleeckal G., Akgün, Eyup, Portoghese, Philip S., Miller, Laurence J.
Publicado em 2010

Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model

Por Smeester, Branden A., Lunzer, Mary M., Akgün, Eyup, Beitz, Alvin J., Portoghese, Philip S.
Publicado no Eur J Pharmacol (2014)

A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance

Por Dutta, Raini, Lunzer, Mary M., Auger, Jennifer L., Akgün, Eyup, Portoghese, Philip S., Binstadt, Bryce A.
Publicado no Arthritis Res Ther (2018)

Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception

Por Akgün, Eyup, Javed, Muhammad I., Lunzer, Mary M., Smeester, Branden A., Beitz, Al J., Portoghese, Philip S.
Publicado em 2013

MDAN-21: A Bivalent Opioid Ligand Containing mu-Agonist and Delta-Antagonist Pharmacophores and Its Effects in Rhesus Monkeys

Por Aceto, Mario D., Harris, Louis S., Negus, S. Stevens, Banks, Matthew L., Hughes, Larry D., Akgün, Eyup, Portoghese, Philip S.
Publicado no Int J Med Chem (2012)

Bivalent ligands that target mu opioid (MOP) and cannabinoid1 (CB(1)) receptors are potent analgesics devoid of tolerance

Por Naour, Morgan Le, Akgün, Eyup, Yekkirala, Ajay, Lunzer, Mary M., Powers, Mike D., Kalyuzhny, Alexander E., Portoghese, Philip S.
Publicado em 2013

INHIBITION OF INFLAMMATORY AND NEUROPATHIC PAIN BY TARGETING A MU OPIOID RECEPTOR/CHEMOKINE RECEPTOR5 HETEROMER (MOR-CCR(5))

Por Akgün, Eyup, Javed, Muhammad I., Lunzer, Mary M., Powers, Michael D., Sham, Yuk Y., Watanabe, Yoshikazu, Portoghese, Philip S.
Publicado no J Med Chem (2015)

The bivalent ligand, MMG22, reduces neuropathic pain after nerve injury without the side effects of traditional opioids

Por Speltz, Rebecca, Lunzer, Mary M., Shueb, Sarah S., Akgün, Eyup, Reed, Rachelle, Kalyuzhny, Alex, Portoghese, Philip S., Simone, Donald A.
Publicado no Pain (2020)

Synthesis and in vitro characterization of radioiodinatable benzodiazepines selective for type 1 and 2 cholecystokinin receptors

Por Akgün, Eyup, Körner, Meike, Gao, Fan, Harkumar, Kaleeckal G., Waser, Beatrice, Reubi, Jean Claude, Portoghese, Philip S., Miller, Laurence J.
Publicado em 2009

Induced association of mu opioid (MOP) and type 2 cholecystokinin (CCK(2)) receptors by novel bivalent ligands

Por Zheng, Yaguo, Akgün, Eyup, Harikumar, Kaleeckal G., Hopson, Jessika, Powers, Michael D., Lunzer, Mary M., Miller, Laurence J., Portoghese, Philip S.
Publicado em 2009

The Bivalent Ligand MCC22 Potently Attenuates Hyperalgesia in a Mouse Model of Cisplatin-Evoked Neuropathic Pain without Tolerance or Reward

Por Cataldo, Giuseppe, Erb, Samuel J., Lunzer, Mary M., Luong, Nhungoc, Akgün, Eyup, Portoghese, Philip S., Olson, Julie K., Simone, Donald A.
Publicado no Neuropharmacology (2019)

Targeting MOR-mGluR(5) heteromers reduces bone cancer pain by activating MOR and inhibiting mGluR5

Por Shueb, Sarah S., Erb, Samuel J., Lunzer, Mary M., Speltz, Rebecca, Harding-Rose, Catherine, Akgün, Eyup, Simone, Donald A., Portoghese, Philip S.
Publicado no Neuropharmacology (2019)

The bivalent ligand MCC22 potently attenuates nociception in a murine model of sickle cell disease

Por Cataldo, Giuseppe, Lunzer, Mary M., Olson, Julie K., Akgün, Eyup, Belcher, John D., Vercellotti, Gregory M., Portoghese, Philip S., Simone, Donald A.
Publicado no Pain (2018)

The combination of a delta-opioid receptor agonist and loperamide produces peripherally-mediated analgesic synergy in mice

Por Bruce, Daniel.J., Peterson, Cristina.D., Kitto, Kelley. F., Akgün, Eyup., Lazzaroni, Sophia., Portoghese, Phillip.S., Fairbanks, Carolyn. A., Wilcox, George. L.
Publicado no Anesthesiology (2019)

A bivalent ligand that activates mu opioid receptor and antagonizes mGluR5 receptor reduces neuropathic pain in mice

Por Peterson, Cristina D., Kitto, Kelley F., Akgün, Eyup, Lunzer, Mary M., Riedl, Maureen S., Vulchanova, Lucy, Wilcox, George L., Portoghese, Philip S., Fairbanks, Carolyn A.
Publicado no Pain (2017)

Molecular Basis for Binding and Subtype Selectivity of 1,4-Benzodiazepine Antagonist Ligands of the Cholecystokinin Receptor

Por Cawston, Erin E., Lam, Polo C. H., Harikumar, Kaleeckal G., Dong, Maoqing, Ball, Alicja M., Augustine, Mary Lou, Akgün, Eyup, Portoghese, Philip S., Orry, Andrew, Abagyan, Ruben, Sexton, Patrick M., Miller, Laurence J.
Publicado em 2012