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INHIBITION OF INFLAMMATORY AND NEUROPATHIC PAIN BY TARGETING A MU OPIOID RECEPTOR/CHEMOKINE RECEPTOR5 HETEROMER (MOR-CCR(5))
Chemokine release promotes crosstalk between opioid and chemokine receptors that in part leads to reduced efficacy of morphine in the treatment of chronic pain. Based on the possibility that a MOR-CCR(5) heteromer is involved in such crosstalk, we have synthesized bivalent ligands (MCC series) that...
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| Publicado no: | J Med Chem |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5055304/ https://ncbi.nlm.nih.gov/pubmed/26451468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01245 |
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