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Targeting putative mu opioid/metabotropic glutamate receptor-5 heteromers produces potent antinociception in a chronic murine bone cancer model

The therapeutic management of chronic pain associated with many cancers is problematic due to development of tolerance and other adverse effects during the disease progression. Recently we reported on a bivalent ligand (MMG22) containing both mu agonist and mGluR(5) antagonist pharmacophores that pr...

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Detalhes bibliográficos
Publicado no:Eur J Pharmacol
Main Authors: Smeester, Branden A., Lunzer, Mary M., Akgün, Eyup, Beitz, Alvin J., Portoghese, Philip S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4259840/
https://ncbi.nlm.nih.gov/pubmed/25239072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2014.09.008
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